Rapid Review: Kawasaki Disease

Reviewed February 2024

Kawasaki Disease

• Children < 5 years old
• History of high fever × 5 days
• Conjunctivitis, rash, adenopathy, strawberry tongue, hand or foot edema, fever
• Leading cause of pediatric acquired heart disease, risk for coronary artery aneurysm
• CRASH and burn: conjunctivitis, rash, adenopathy, strawberry tongue, hand or foot edema, uncontrolled high fever
• Tx: IVIG + aspirin

Sample question:

A 4-year-old boy presents to the emergency department with his parents because of a rash and fever for 7 days. His temperature is 102.9°F (39.4°C) and heart rate is 120 bpm. Physical examination demonstrates bilateral conjunctival injection, an erythematous tongue, and anterior cervical lymphadenopathy. The patient has a maculopapular rash involving the trunk, hands, and feet. Which of the following is the most likely cause of these symptoms?