Rapid Review: Multiple Myeloma

Reviewed February 2024

Multiple Myeloma

• Patient will be older
• Back pain
• Signs and symptoms: CRAB: hypercalcemia, renal insufficiency, anemia, lytic bone lesions or back pain
• Labs will show monoclonal antibody spike
• X-ray will show lytic lesions
• Peripheral blood smear: rouleaux formations
• Serum protein electrophoresis: M spike
• Protein electrophoresis urine analysis: Bence Jones proteins
• Most commonly caused by single clone plasma cell malignancy